In terms of administration the region is divided into 13 districts:
There are 666 communities in the region, of which 23 are classed as town. The Prešov region has a higher population than any other in Slovakia although its density of population is the second lowest in the country. Almost 50 % of the region’s inhabitants live in its towns, the largest of which is the regional capital, Prešov, the third largest city in Slovakia with a population of 91,767.